Register for citation alerts

An alternative is the use of an antiseptic barrier cap, which cleans the catheter hub by continuous passive disinfection” Voor In ‘t Holt et al (2017).


BACKGROUND: Microorganisms can intraluminally access a central venous catheter via the catheter hub. The catheter hub should be appropriately disinfected to prevent central line-associated bloodstream infections (CLABSIs). However, compliance with the time-consuming manual disinfection process is low. An alternative is the use of an antiseptic barrier cap, which cleans the catheter hub by continuous passive disinfection.

ReTweet if useful… Adding antiseptic barrier caps to central-line maintenance bundles @ivteam #ivteam

OBJECTIVE: To compare the effects of antiseptic barrier cap use and manual disinfection on the incidence of CLABSIs.

DESIGN: Systematic review and meta-analysis.

METHODS: We systematically searched Embase, Medline Ovid, Web-of-science, CINAHL EBSCO, Cochrane Library, PubMed Publisher and Google Scholar until May 10, 2016. The primary outcome, reduction in CLABSIs per 1000 catheter-days, expressed as an incidence rate ratio (IRR), was analyzed with a random effects meta-analysis. Studies were included if 1) conducted in a hospital setting, 2) used antiseptic barrier caps on hubs of central lines with access to the bloodstream and 3) reported the number of CLABSIs per 1000 catheter-days when using the barrier cap and when using manual disinfection.

RESULTS: A total of 1537 articles were identified as potentially relevant and after exclusion of duplicates, 953 articles were screened based on title and abstract; 18 articles were read full text. Eventually, nine studies were included in the systematic review, and seven of these nine in the random effects meta-analysis. The pooled IRR showed that use of the antiseptic barrier cap was effective in reducing CLABSIs (IRR=0.59, 95% CI=0.45-0.77, P<0.001).

CONCLUSIONS: Use of an antiseptic barrier cap is associated with a lower incidence CLABSIs and is an intervention worth adding to central-line maintenance bundles.


Voor In ‘t Holt, A.F., Helder, O.K., Vos, M.C., Schafthuizen, L., Sülz, S., van den Hoogen, A. and Ista, E. (2017) Antiseptic barrier cap effective in reducing central line-associated bloodstream infections: A systematic review and meta-analysis. International Journal of Nursing Studies. January 22nd. .

doi: 10.1016/j.ijnurstu.2017.01.007.

Thank you to our partners for supporting IVTEAM