OPAT for infective endocarditis patients – Full Text
“In a setting where there was good adherence to BSAC criteria, treating IE patients using OPAT services was safe. Complications observed were likely independent of treatment location. Significant bed days were saved” Schwiebert et al (2024).
Self-administered outpatient parenteral antimicrobial treatment
“As OPAT services expand their inclusion criteria to include complex patient populations, there is an increased need for selecting appropriate patients to receive either healthcare-administered OPAT (H-OPAT) or self-administered OPAT (S-OPAT)” Brand et al (2024).
Ceftazidime-avibactam stability in elastomeric infusion devices – Full Text
“To evaluate the stability of ceftazidime/avibactam in elastomeric infusers, utilizing the UK’s Yellow Cover Document (YCD) stability testing framework, in conditions representative of OPAT practice” Naicker et al (2024).
Health-related quality of life in OPAT patients
“OPAT is associated with improved patient-reported quality of life and facilitates early return to work or school. Nevertheless, it is crucial to closely monitor patients with a lower baseline quality of life to optimize their overall OPAT experience” Durojaiye and Kritsotakis (2024).
Dalbavancin OPAT treatment – Full Text
“We present a case of a homeless patient with MRSA bacteremia and osteomyelitis successfully treated with dalbavancin. Our case highlights the potential of dalbavancin’s once-weekly dosing to improve adherence and treatment outcomes in challenging outpatient scenarios” Sabina et al (2024).
OPAT services in Germany – Full Text
“The study demonstrates that OPAT can be safely conducted in Germany. In preparation for its broader implementation, crucial next steps include creating medical guidelines, fostering interdisciplinary and inter-sectoral communication, as well as creating financial and structural regulations that facilitate and encourage the adoption of OPAT” Schmidt-Hellerau et al (2024).
Electronic medical record tracking of OPAT patients – Full Text
“Bundled multimodal modifications to the local EHR increased patient care efficiency and staff satisfaction and facilitated data collection to support a large OPAT program” Munsiff et al (2024).
OPAT effectiveness and antimicrobial stewardship – Full Text
“This study demonstrates the impact of an OPAT service in the framework of AMS as well as its benefits for the hospital whilst preserving safety and efficacy for the patient’s parenteral antimicrobial treatment” Burch et al (2024).
Blueprint for OPAT standardization – Full Text
“We intend our registry to serve as a blueprint for similar OPAT programs with limited administrative resources. Wider application of our system would allow for easier aggregation and comparisons of OPAT practice and address the lack interinstitutional standardization of OPAT data and outcomes” Canterino et al (2024).
Successful OPAT service implementation – Full Text
“Challenges and facilitators to OPAT service were identified among patients, health professionals, OPAT service providers, and health care administrators. Understanding them is crucial to designing targeted initiatives for successful OPAT service implementation” Mohammed et al (2024).
Effectiveness of continuous flucloxacillin infusion in OPAT – Full Text
“Our review supports the assertion that continuous infusion flucloxacillin is clinically effective and well tolerated for the treatment of complicated MSSA infection in the OPAT setting” Clarkson and Snape (2024).
Outpatient treatment for MSSA infection – Full Text
“In this cohort of MSSA BSI patients discharged on OPAT, there were no differences in outcomes of readmission with the same infection and 90-day all-cause readmission in patients treated with ceftriaxone compared to oxacillin/nafcillin or cefazolin” Hamad et al (2024).
Elastomeric infusion pump in OPAT – Full Text
“Outpatient antimicrobial therapy in elastomeric infusion pumps is an alternative in patients requiring prolonged intravenous treatment, and age is not a conditioning factor for inclusion in these programs” Ferro Rodríguez et al (2024).
OPAT osteomyelitis treatment case report – Full Text
“Administration of Cefiderocol via OPAT can present a safe and effective option for treatment of post-traumatic osteomyelitis with multi-drug resistant Pseudomonas aeruginosa” Schellong et al (2024).
Complications of midline catheters in pediatric OPAT – Full Text
“Using midline catheters, 76% of patients could complete their intended iv therapy without the need for additional venous access” Fläring et al (2024).
Intravenous vancomycin to oral antibiotic switch
“The objective of this study was to evaluate the safety and effectiveness of transitioning to oral therapy compared to continuing parenteral vancomycin in patients with orthopedic infections” Gallagher et al (2023).
OPAT experience with dalbavancin – Full Text
“This report adds to clinical experience with dalbavancin for off-label indications whilst further validating its role in ABSSSI. Dalbavancin as primary therapy in deep-seated infections merits investigation in formal clinical trials” McSorley et al (2024).
Elastomeric pump drug stability study – Full Text
“Our objective was to investigate the stability of nine antipseudomonal and broad-spectrum beta lactam antibiotics (aztreonam, cefepime, cefiderocol, ceftazidime, ceftazidime/avibactam, ceftolozane/tazobactam, meropenem, meropenem/vaborbactam, and piperacillin/tazobactam) to allow the spread of OPAT programs” Fernández-Rubio et al (2023).
OPAT worldwide survey – Full Text
“In this first worldwide survey on OPAT, we explored the current OPAT services around the world, adherence to recommendations and identified best practices and challenges from different perspectives” Hassanzai et al (2023).
Laboratory monitoring regimens for OPAT – Full Text
“We identified 2.7 OPAT-AEs per 1000 sets of weekly laboratory tests in this population, suggesting that less intensive laboratory monitoring may be safe and reasonable” Sunagawa et al (2023).
Home-based and facility-based OPAT – Full Text
“In this systematic literature review and meta-analysis, we did not find a statistically significant difference in readmission and treatment failure rates between home-based and facility-based OPAT” Hasegawa et al (2023).
Community hospital based OPAT services – Full Text
“An outpatient parenteral antimicrobial therapy team from a Veterans Affairs facility managed patients discharged from their own facility and neighboring community hospitals” Tiemann et al (2023).
Lessons learnt from home apomorphine infusions – Full Text
“Home initiation of APO infusion can be undertaken successfully and has benefits for both patients and healthcare teams. This protocol will now continue as a standard of care at our centre” Kobylecki and Partington-Smith (2023).
OPAT in rural areas – Full Text
“This article reviews existing literature regarding outpatient parenteral antimicrobial therapy in rural settings and explores existing barriers and potential solutions that may be of assistance to providers looking to provide these services” Mehta et al (2023).
Economic comparison of OPAT antimicrobial stewardship – Full Text
“The application of antimicrobial stewardship (AMS) principles may entail increased cost to allow for narrower-spectrum therapy. Prescribing benzylpenicillin (BP) and ceftriaxone (CRO) for outpatient parenteral antimicrobial therapy (OPAT) demonstrates the complex challenge of this principle” Kalatharan et al (2023).
Outpatient parenteral antimicrobial therapy review – Full Text
“OPAT enables better patient-centred healthcare close to home. The length of hospital stay can be reduced and adverse events due to prolonged hospitalisation can be avoided” Kilinc et al (2023)
OPAT implementation bundle
“Within a Belgian, single, large community-based hospital, a multimodal intervention bundle resulted in increases in OPAT implementation, infection complexity, and required treatment durations without statistically significant differences in outcomes” Missiaen et al (2023).
OPAT osteomyelitis treatment – Full Text
“He was successfully treated with surgical debridement combined with the administration of teicoplanin plus rifampicin in the outpatient setting, completing, in total, a twelve-week course of antibiotic therapy” Papaetis et al (2023).
Role clinical microbiology laboratory in OPAT – Full Text
“Optimal care of patients requiring long-term outpatient parenteral or oral antimicrobial therapy by infectious diseases (ID) specialists is facilitated by an accurate microbiologic diagnosis” Optimal care of patients requiring long-term outpatient parenteral or oral antimicrobial therapy by infectious diseases (ID) specialists is facilitated by an accurate microbiologic diagnosis et al (2023).
OPAT management of bronchiectasis – Full Text
“This study assessed outcomes in both cystic fibrosis (CF) and non-CF bronchiectasis patients who received OPAT for the management of an acute exacerbation of bronchiectasis” Tu et al (2023).