Drug alert: Intravenous dantrolene and the risk of undissolved crystals

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MHRA report “Some newly issued vials of intravenous dantrolene may contain crystals of undissolved dantrolene sodium following reconstitution. Draw up the reconstituted solution with a filter needle to prevent these crystals from being administered to patients. There may be a residual increased risk of injection site reactions due to crystals that may not have been removed by filtration; heightened vigilance is therefore required.”

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