Molecule may help defeat vascular access device biofilm


Intravenous news: Med Page Today report “Inhibiting a key chaperone molecule involved in cellular signaling may help defeat otherwise treatment-resistant fungal infections associated with catheters and other indwelling devices, researchers reported in PLoS Pathogens. The molecule, known as Hsp90, regulates cellular circuitry and important growth processes including yeast-to-filament transition in biofilm-forming fungi such as Candida albicans.

Biofilms are a common feature among fungi and bacteria that colonize indwelling medical devices, as they protect the organisms from chemical attack and also physical forces that might otherwise dislodge them.

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