Intravenous literature: Moreno, R.B., Rives, S., Justicia, A., Català, A., Ruiz-Llobet, A., Toll, T. and Estella, J. (2013) Successful port-a-cath salvage using linezolid in children with acute leukemia. Pediatric & Blood Cancer. June 15th. [Epub ahead of print].
Central venous catheter (CVC) removal is indicated when persistent catheter-related bloodstream infection (CRBSI) occurs. This is a retrospective study to analyze the use of linezolid as a salvage therapy for CRBSIs due to coagulase-negative Staphylococci in children diagnosed with acute leukemia. Seven treatment courses of linezolid were administrated to six patients with port-type-CRBSI after non-effective intravenous vancomycin or teicoplanin treatment. Simultaneous lock and systemic therapy with linezolid avoided the removal of port-type-CVC in all cases. Treatment with linezolid was an alternative to catheter removal in these patients. Prospective studies are needed to confirm linezolid effectiveness as a salvage treatment in CRBSI.