Prevention of bacterial biofilm on coated central venous catheters


#IVTEAM #Intravenous literature: Jamal, M.A., Rosenblatt, J.S., Hachem, R.Y., Ying, J., Pravinkumar, E., Nates, J.L., Chaftari, A.M. and Raad, I.I. (2013) Prevention of Gram-Negative Bacterial Biofilm on Minocycline/Rifampin impregnated catheters sequentially coated with Chlorhexidine. Antimicrobial Agents and Chemotherapy. October 28th. [epub ahead of print].


Resistant gram-negative bacteria are increasing central line associated blood stream infection threats. To better combat this, chlorhexidine (CHX) was added to Minocycline-Rifampin (M/R) catheters. Antimicrobial activity of the CHX-M/R catheters was tested in vitro against multi-drug resistant, gram-negative Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. M/R and chlorohexidine-silver sulfadiazine catheters (CHX/SS) were used as comparators. The novel CHX-M/R was significantly more effective (P < 0.0001) than CHX/SS or M/R in preventing biofilm colonization and in antimicrobial durability.

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