Pre-filled normal saline syringes reduce central venous access device (CVAD) associated bloodstream infection


Intravenous literature: Bertoglio, S., Rezzo, R., Merlo, F.D., Solari, N., Palombo, D., Vassallo, F., Beltramini, S. and Demaria, A. (2013) Pre-filled normal saline

syringes to reduce totally implantable venous access device-associated bloodstream infection: a single institution pilot study. The Journal of Hospital Infection. March 13th. [Epub ahead of print].


Flushing totally implantable venous access devices (TIVADs) with manually filled saline syringes may increase contamination and catheter-related bloodstream infection (CRBSI). We used a retrospective cohort study to assess the impact of changing from manually filled syringes to manufactured pre-filled syringes on the frequency of CRBSI in 718 TIVADs. Manually filled syringes were used in 269 patients and pre-filled syringes in 449. The CRBSI rate was 2.7% in the pre-filled syringe group and 6.3% in the manually filled syringe group (P = 0.016). Sex, tumour type and stage, access site and access body side were not independent risk factors for CRBSI.

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