Needleless IV connector septum contamination assay


Intravenous literature: Luchsinger, B., Schallenberger, M. and Meyer, T. (2011) Development of an In vitro Septum Contamination Assay for a Measuring the Activity of Antimicrobial Needleless Connectors. AJIC: American Journal of Infection Control. 39(5), p.E42-E43.


The introduction of the needleless IV connector (NC) in the 1990s was accompanied by an increase in the occurrence of CABSIs. A consequence of the general design of a NC is that upon activation, the environmentally exposed septum comes in contact with the IV fluid or a component of the NC’s sterile interior. Microbial contamination of the septum has been implicated as the source of pathogens leading to CABSIs. To this end, several companies have introduced NCs that contain an antimicrobial agent on the exposed septum. Herein we report an assay that measures the activity of an antimicrobial NC in reducing organism contamination on the exposed septum, and demonstrate its effectiveness in measuring the activity antimicrobial of one such NC.

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