Intravenous literature: Schrijvers, L.H., Beijlevelt-van der Zande, M., Peters, M., Schuurmans, M.J. and Fischer, K. (2012) Learning intravenous infusion in haemophilia: experience from the Netherlands. Haemophillia. Feb 1. [Epub ahead of print].
Summary. Nowadays, nearly all severe haemophilia patients in the Netherlands practice self infusion at home. Learning intravenous administration of clotting factor requires time and effort. In order to inform patients about the burden and time-investment needed to learn intravenous infusion, we performed a two-centre retrospective study. All data on the learning processes, involving haemophilia patients born between 1980 and 2010 treated in Utrecht or Amsterdam, were extracted from patient files. A total of 154 patients and their parents were analysed (168 learning processes). Almost all patients had severe haemophilia and started prophylaxis at a median age of 2.7â€ƒyears. 152/154 patients successfully learned intravenous infusion, including nine patients who temporally stopped and succeeded later. Overall, parents or patients needed a median of eight visits (IQR 4.3-14) in a median of 7â€ƒweeks (IQR 4-14.8) to learn home treatment. Parents who began to infuse by CVAD started at a median age of 1.9â€ƒyears and succeeded within a median of 12 visits during 7.5â€ƒweeks. Parents who learned to perform intravenous infusion started at a median age of 4â€ƒyears and needed 11 visits during 9â€ƒweeks. In 77% of cases, the mother was the first who started learning to infuse the child. Patients started with self infusion at a median age of 12.9â€ƒyears, requiring a median of five visits in 12â€ƒweeks. The majority of patients and parents were able to learn intravenous infusion, with 50% of all parents and patients succeeding within eight visits during 7â€ƒweeks.