Intraosseous administration of Tissue Plasminogen Activator

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We describe 3 cases in which tPA was administered via IO access on a mobile stroke unit as part of the Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services (BEST-MSU) trial” Bowry et al (2018).

Abstract:

Mobile stroke units offer improved time to administration of thrombolytics for ischemic stroke patients. Acquisition of intravenous (IV) access, however, can be challenging in the pre-hospital environment leading to treatment delays. Intraosseous (IO) access is commonly used in the pre-hospital setting for a variety of conditions and may serve as a viable means for tPA (tissue plasminogen activator) administration. We describe 3 cases in which tPA was administered via IO access on a mobile stroke unit as part of the Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services (BEST-MSU) trial. No adverse events were observed in the process of obtaining IO access or administering tPA.

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Reference:

Bowry, R., Nour, M., Kus, T., Parker, S., Stephenson, J., Saver, J., Grotta, J.C. and Ostermayer, D. (2018) Intraosseous Administration of Tissue Plasminogen Activator on a Mobile Stroke Unit. Prehospital Emergency Care. September 20th. .

doi: 10.1080/10903127.2018.1526355.

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