Feasibility of home infusion and self-administration of Nanofiltered C1 Esterase Inhibitor


#IVTEAM #Intravenous literature: Gregory, C., Landmesser, L.M., Corrigan, L. and Mariano, D. (2014) Feasibility of Home Infusion and Self-Administration of Nanofiltered C1 Esterase Inhibitor for Routine Prophylaxis in Patients With Hereditary Angioedema and Characterization of a Training and Support Program. Journal of Infusion Nursing. 37(1), p.29–34.


Hereditary angioedema (HAE) is a rare, chronic disease of C1 inhibitor deficiency. Study researchers evaluated the prevalence of home and self-administration of nanofiltered, human-derived C1 esterase inhibitor infusions and the implementation of a nursing training and support program. Home administration rate increased from 49.0% to 75.8%. The percentage who self-administered increased from 20.3% to 43.9%. Doses per week averaged 1.85 at home compared with 1.40 in infusion centers and physicians’ offices. Patients required an average of 5 visits to be trained. Self-administration is a viable, feasible option in the management of HAE, which is facilitated by a nurse-managed training and support program.

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