Effectiveness and safety of OPAT delivered ertapenem

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Ertapenem OPAT was effective and safe. Caregivers in nursing homes should be better trained in OPAT-related procedures” Sanroma et al (2018).

Abstract:

AIM: To evaluate the effectiveness and safety of ertapenem in patients hospitalized at home.

PATIENTS & METHODS: Retrospective analysis of data from Spanish Outpatient Parenteral Antimicrobial Therapy (OPAT) registry.

RESULTS: Data from 1428 patients (median age 70 years; 5.4% institutionalized) and 1547 infectious processes (24% self-administration) were analyzed. Clinical cure or improvement was achieved in 93.8% of cases. Rate of related readmissions was 4.2%, of clinically important complications -3.9%, and of adverse drug reactions -3.2%. High comorbidity burden, contagion in nursing home and certain types of infection were associated with worse prognosis. Self-administration was effective and safe, except in case of nursing home-acquired infections.

CONCLUSION: Ertapenem OPAT was effective and safe. Caregivers in nursing homes should be better trained in OPAT-related procedures.

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Reference:

Sanroma, P., Muñoz, P., Mirón-Rubio, M., Aguilera, A., Estrada, O., García, D., González-Ramallo, V.J., Pajarón, M., Sgaramella, G.A., González, C.R., Mujal, A., Abad, A., Solé, A., González, S., Escalada, C., Vitoria, I., Gómez, M.J., Parra, J.J., Sampedro, I. and Pereda, I. (2018) Effectiveness and safety of ertapenem used in hospital-at-home units: data from Spanish Outpatient Parenteral Antimicrobial Therapy Registry. Future Microbiology. September 21st. .

doi: 10.2217/fmb-2018-0065.

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