This study aimed to identify whether patients with advanced cancers were at high risk of peripherally inserted central catheter (PICC)-related complications when treated with concurrent chemo-radiotherapy” Xie et al (2017).
AIMS AND OBJECTIVES: This study aimed to identify whether patients with advanced cancers were at high risk of peripherally inserted central catheter (PICC)-related complications when treated with concurrent chemo-radiotherapy.
BACKGROUND: PICCs are widely used in chemotherapy. However, catheter usage may elevate the risks of infections and thrombosis. It is important to identify the patients with high risk of PICC-related complications. To date, little is known about PICC-related complications in patients with advanced cancers and receiving concurrent chemo-radiotherapy.
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DESIGN: Five hundred sixty-nine cancer patients with advanced cancers and treated by chemo-radiotherapy were analyzed in the study. The incidences of PICC-related complications were investigated.
METHODS: Univariable and multivariable logistic regression analyses were employed for identification of risk factors.
RESULTS: Eighty-six (15.1%) patients exhibited PICC-related infectious complications, of which 6.3% were local infection, 3.9% were catheter-related bloodstream infection (CRBSI) and 4.9% were exit-site infection. Sixty-five (11.4%) developed symptomatic PICC-related thrombosis and fifty-two (9.1%) were suffering from phlebitis. The overall complication rate was 53.1%. The univariable logistic regression and multivariate analysis showed that comorbidity (OR 1.51, P=0.0148) and body mass index (BMI) (OR 1.46, P=0.0157), and duration of radio-chemotherapy (OR 1.4733, P=0.0049) were significantly associated with PICC-related complications. Patients with PICC-related complications showed lower 5-year survival rate than those without PICC-related complications.
CONCLUSIONS: Identification of risk factors of PICC-related complications in patients with advanced cancer before catheter usage may play an important role in improvement of the prognosis.
Xie, J., Xu, L., Xu, X. and Huang, Y. (2017) Complications of peripherally inserted central catheters in advanced cancer patients undergoing combined radiotherapy and chemotherapy. Journal of clinical nursing. March 23rd. [Epub ahead of print].
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