Comparison of chlorhexidine-gluconate and povidone-iodine for skin antisepsis at CVC sites


#IVTEAM #Intravenous literature: “Chlorhexidine-gluconate ethanol was superior to povidone-iodine to reduce skin colonizers at CVC sites.” Yamamoto et al (2014).


Yamamoto, N., Kimura, H., Misao, H., Matsumoto, H., Imafuku, Y., Watanabe, A., Mori, H., Yoshida, A., Miura, S., Abe, Y., Toba, M., Suzuki, H., Ogawa, K. and Kanemitsu, K. (2014) Efficacy of 1.0% chlorhexidine-gluconate ethanol compared with 10% povidone-iodine for long-term central venous catheter care in hematology departments: A prospective study. American Journal of Infection Control. March 18th. [epub ahead of print].


The efficacy of 1% chlorhexidine-gluconate ethanol and 10% povidone-iodine for skin antisepsis of central venous catheter (CVC) sites were compared among hematology patients. The CVC site colonization rates of those groups were 11.9% and 29.2%, respectively, and the catheter-associated blood stream infections were 0.75 and 3.62 per 1,000 catheter-days, respectively. One percent chlorhexidine-gluconate ethanol was superior to povidone-iodine to reduce skin colonizers at CVC sites even when catheters were used for long duration.

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