Catheter-related bloodstream infections caused by Gram-negative bacteria


#IVTEAM #Intravenous literature: Bouza, E., Eworo, A., Fernández Cruz, A., Reigadas, E., Rodríguez-Créixems, M. and Muñoz, P. (2013) Catheter-related bloodstream infections caused by Gram-negative bacteria. The Journal of Hospital Infection. September 18th. [epub ahead of print].


From 2008 to 2010, patients with microbiologically confirmed Gram-negative catheter-related bloodstream infection (GN-CRBSI) were each compared with two randomly selected controls. We included 81 cases (17% of all CRBSI) and 162 controls with CRBSI caused by other pathogens. Incidence of GN-CRBSI was 0.53 episodes per 1000 admissions. Cases were more likely to have underlying neurological disease or gastrointestinal conditions, previous antimicrobial therapy and a shorter time to blood culture positivity. Surgery in the present admission (odds ratio: 3.5), P. aeruginosa (3.6) and a complicated bacteraemia (4.1) were related to a higher mortality rate. GN-CRBSI accounts for 17% of all CRBSI and should be taken into consideration in the empirical therapy of patients with the characteristics mentioned above.

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