Blood culture contamination rate study compares chlorhexidine and povidone iodine

Safety IV catheter

Intravenous literature: Nuntnarumit, P. and Sangsuksawang, N. (2013) A Randomized Controlled Trial of 1% Aqueous Chlorhexidine Gluconate Compared with 10% Povidone-Iodine for Topical Antiseptic in Neonates: Effects on Blood Culture Contamination Rates. Infection Control and Hospital Epidemiology. 34(4), p.430-432


We conducted a randomized controlled trial in neonates with birth weight greater than or equal to 1,500 g that compared 1% aqueous chlorhexidine gluconate (CHG) with 10% povidone–iodine (PI) as a topical antiseptic. We found 1% CHG to be more effective than 1% PI in reducing blood culture contamination rates, and no contact dermatitis was observed.

Main page


Comments are closed.