Antibiotic levels: Comparison of central venous catheter and peripheral vein samples


Intravenous literature: Wilson, K. and Jamerson, P.A. (2013) Comparison of central venous catheter and peripheral vein samples of antibiotics in children with cystic fibrosis. Journal for Specialists in Pediatric Nursing. 18(1), p.33-41.


PURPOSE: To determine if accurate serum antibiotic levels can be obtained from central venous catheters (CVCs) in pediatric patients with cystic fibrosis.

DESIGN AND METHODS: Fifty paired CVC-peripheral vancomycin or tobramycin specimens were collected within 5?min of each other following a 5-ml flush and discard. Specimen samples were randomized by first site drawn.

RESULTS: CVC-peripheral antibiotic levels were highly correlated (r =.97, p <.001), with no statistically significant difference (t = 1.18, p =.25). Bland-Altman plot analysis revealed a bias of.47, with limits of agreement ranging from -4.20 to 6.87.

PRACTICE IMPLICATIONS: Accurate antibiotic concentrations can be obtained from CVCs, reducing pediatric patient trauma and stress.

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